Issue 6, 2014
From the journal:

Lab on a Chip

Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release†

Bárbara Herranz-Blanco,a   Laura R. Arriaga,b   Ermei Mäkilä,ac   Alexandra Correia,a   Neha Shrestha,a   Sabiruddin Mirza,ab   David A. Weitz,b   Jarno Salonen,c   Jouni Hirvonena  and  Hélder A. Santos*a  

* Corresponding authors

a Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland
E-mail: helder.santos@helsinki.fi
Fax: +358 9 191 59144
Tel: +358 9 191 59661

b Department of Physics, School of Engineering and Applied Science, Harvard University, MA 02138, USA

c Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Finland

Abstract

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi–lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

Graphical abstract: Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3LC51260F
Article type
Communication
Submitted
11 Nov 2013
Accepted
06 Jan 2014
First published
06 Jan 2014
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2014,14, 1083-1086

Author version available

Download author version (PDF)

Permissions

Request permissions

Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

B. Herranz-Blanco, L. R. Arriaga, E. Mäkilä, A. Correia, N. Shrestha, S. Mirza, D. A. Weitz, J. Salonen, J. Hirvonen and H. A. Santos, Lab Chip, 2014, 14, 1083 DOI: 10.1039/C3LC51260F

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements