Enhanced MRI relaxivity of aquated Gd3+ ions by carboxyphenylated water-dispersed graphene nanoribbons

Ayrat Gizzatov; Vazrik Keshishian; Adem Guven; Ayrat M. Dimiev; Feifei Qu; Raja Muthupillai; Paolo Decuzzi; Robert G. Bryant; James M. Tour; Lon J. Wilson

doi:10.1039/C3NR06026H

Enhanced MRI relaxivity of aquated Gd³⁺ ions by carboxyphenylated water-dispersed graphene nanoribbons†

Ayrat Gizzatov,^a Vazrik Keshishian,^a Adem Guven,^a Ayrat M. Dimiev,^a Feifei Qu,^b Raja Muthupillai,^b Paolo Decuzzi,^c Robert G. Bryant,^d James M. Tour*^a and Lon J. Wilson*^a

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^a Department of Chemistry, Richard E. Smalley Institute for Nanoscale Science and Technology, Rice University, 6100 Main Street, Hoston, TX-77005, USA
E-mail: tour@rice.edu, durango@rice.edu

^b Department of Radiology, St. Luke's Episcopal Hospital, 6720 Bertner Avenue, MC 2-270, Houston, TX-77030-2697, USA

^c Department of Translational Imaging, The Methodist Hospital Research Institute, 6560 Fannin St., Houston, TX-77030, USA

^d Department of Chemistry, University of Virginia, Charlottesville, VA-22904-4319, USA

Abstract

The present study demonstrates that highly water-dispersed graphene nanoribbons dispersed by carboxyphenylated substituents and conjugated to aquated Gd³⁺ ions can serve as a high-performance contrast agent (CA) for applications in T₁- and T₂-weighted magnetic resonance imaging (MRI) with relaxivity (r_1,2) values outperforming currently-available clinical CAs by up to 16 times for r₁ and 21 times for r₂.

Nanoscale

Enhanced MRI relaxivity of aquated Gd³⁺ ions by carboxyphenylated water-dispersed graphene nanoribbons†

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Enhanced MRI relaxivity of aquated Gd³⁺ ions by carboxyphenylated water-dispersed graphene nanoribbons

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