Pd-catalyzed cross-coupling reactions of less activated alkenyl electrophiles (for tosylates and mesylates) with tosylhydrazones: synthesis of various 1,3-dienes

Abstract

Palladium catalyzed cross coupling reaction engaging N-tosylhydrazones of corresponding ketones as a nucleophilic coupling partner and various alkenyl tosylates and mesylates as an electrophiles for the synthesis of various alkenyl derivatives. The salient features of this reactions are (1) no stoichiometric organometallic reagents required, (2) it tolerates a wide range of functional groups, (3) easy to handle and required mild conditions.