Issue 1, 2015

“AND” logic gate regulated pH and reduction dual-responsive prodrug nanoparticles for efficient intracellular anticancer drug delivery

Abstract

A dual-responsive drug delivery system simulating an AND logic gate is developed by core-cross-linking of a disulfide-containing anticancer prodrug with Cu2+ for safe and efficient delivery of anticancer drugs. These prodrug nanoparticles are stable and exhibit nearly no premature drug release, and allow a fast drug release under simulated intracellular conditions, realizing a precise drug delivery towards cell nuclei.

Graphical abstract: “AND” logic gate regulated pH and reduction dual-responsive prodrug nanoparticles for efficient intracellular anticancer drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
05 Sep 2014
Accepted
03 Nov 2014
First published
03 Nov 2014

Chem. Commun., 2015,51, 93-96

“AND” logic gate regulated pH and reduction dual-responsive prodrug nanoparticles for efficient intracellular anticancer drug delivery

L. Bai, X. Wang, F. Song, X. Wang and Y. Wang, Chem. Commun., 2015, 51, 93 DOI: 10.1039/C4CC07012G

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