Issue 26, 2015
From the journal:

Chemical Communications

The importance of loop length on the stability of i-motif structures†

Sarah P. Gurung,ab   Christine Schwarz,a   James P. Hall,ab   Christine J. Cardina  and  John A. Brazier*c  

* Corresponding authors

a Department of Chemistry, University of Reading, Whiteknights, Reading, Berks, UK

b Diamond Light Source, Chilton, Didcot, Oxfordshire, UK

c School of Pharmacy, University of Reading, Whiteknights, Reading, Berks, UK
E-mail: j.a.brazier@reading.ac.uk

Abstract

Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

Graphical abstract: The importance of loop length on the stability of i-motif structures

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Article information

DOI
https://doi.org/10.1039/C4CC07279K
Article type
Communication
Submitted
17 Sep 2014
Accepted
09 Jan 2015
First published
09 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 5630-5632

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The importance of loop length on the stability of i-motif structures

S. P. Gurung, C. Schwarz, J. P. Hall, C. J. Cardin and J. A. Brazier, Chem. Commun., 2015, 51, 5630 DOI: 10.1039/C4CC07279K

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