Issue 12, 2015
From the journal:

Chemical Communications

Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin†

Hiroaki Kitagishi,*a   Fumihiko Chai,a   Shigeru Negi,b   Yukio Sugiurab  and  Koji Kanoa  

* Corresponding authors

a Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan
E-mail: hkitagis@mail.doshisha.ac.jp

b Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan

Abstract

A convenient and efficient method for intracellular delivery of a water-soluble anionic porphyrin has been developed by utilizing its supramolecular interaction with per-O-methyl-β-cyclodextrin bearing an octaarginine chain as a cell-penetrating peptide.

Graphical abstract: Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin

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Article information

DOI
https://doi.org/10.1039/C4CC09042J
Article type
Communication
Submitted
13 Nov 2014
Accepted
02 Jan 2015
First published
02 Jan 2015

Chem. Commun., 2015,51, 2421-2424

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Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin

H. Kitagishi, F. Chai, S. Negi, Y. Sugiura and K. Kano, Chem. Commun., 2015, 51, 2421 DOI: 10.1039/C4CC09042J

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