Issue 37, 2015
From the journal:

Chemical Communications

“Anion clamp” allows flexible protein to impose coordination geometry on metal ions†‡

Minji Wang,a   Tsz Pui Lai,a   Li Wang,ab   Hongmin Zhang,ca   Nan Yang,ad   Peter J. Sadlerae  and  Hongzhe Sun*a  

* Corresponding authors

a Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China
E-mail: hsun@hku.hk

b Department of Chemistry, Central China Normal University, 152 Luo Yu Road, Wuhan 430079, Hubei Province, P. R. China

c Department of Biology and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, 1088 Xue Yuan Road, Shenzhen 518055, P. R. China

d Department of Physiology, School of Medicine, The Johns Hopkins University, Maryland 21287, Baltimore, USA

e Department of Chemistry, University of Warwick, Coventry, UK

Abstract

X-ray crystal structures of human serum transferrin (77 kDa) with YbIII or FeIII bound to the C-lobe and malonate as the synergistic anion show that the large YbIII ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.

Graphical abstract: “Anion clamp” allows flexible protein to impose coordination geometry on metal ions

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Article information

DOI
https://doi.org/10.1039/C4CC09642H
Article type
Communication
Submitted
02 Dec 2014
Accepted
27 Mar 2015
First published
27 Mar 2015

Chem. Commun., 2015,51, 7867-7870

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“Anion clamp” allows flexible protein to impose coordination geometry on metal ions

M. Wang, T. P. Lai, L. Wang, H. Zhang, N. Yang, P. J. Sadler and H. Sun, Chem. Commun., 2015, 51, 7867 DOI: 10.1039/C4CC09642H

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