Rh(iii)- or Ir(iii)-catalyzed ynone synthesis from aldehydes via chelation-assisted C–H bond activation

Abstract

A Rh(III)- or Ir(III)-catalyzed direct aldehyde C–H alkynylation was developed for the first time as a simple and practical method for the synthesis of ynones. This catalytic reaction proceeds under mild reaction conditions and tolerates a variety of synthetically important functional groups (e.g., chloro, bromo, aldehyde), thus providing a good complement to previous methods.