Issue 24, 2015
From the journal:

Chemical Communications

Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement†

Frank Biedermann,*a   Denisa Hathazia  and  Werner M. Nau*a  

* Corresponding authors

a Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
E-mail: frankbiedermann@daad-alumni.de, w.nau@jacobs-university.de

Abstract

A label-free in situ method to monitor reactions in real time by using fluorescent supramolecular chemosensors based on cucurbit[8]uril is presented. It allows sensing of enzymatic activity, inhibitor and activator screening, and analyte detection with unprecedented versatility and high sensitivity.

Graphical abstract: Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement

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Article information

DOI
https://doi.org/10.1039/C4CC10227D
Article type
Communication
Submitted
22 Dec 2014
Accepted
15 Jan 2015
First published
15 Jan 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4977-4980

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Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement

F. Biedermann, D. Hathazi and W. M. Nau, Chem. Commun., 2015, 51, 4977 DOI: 10.1039/C4CC10227D

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