Issue 37, 2015
From the journal:

Chemical Communications

A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria†

Ke Li,ab   Yang-Yang Zhang,ab   Guo-Yu Jiang,a   Yuan-Jun Hou,a   Bao-Wen Zhang,a   Qian-Xiong Zhou*a  and  Xue-Song Wang*a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

b University of the Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

A piperazine-modified Crystal Violet was found to be able to selectively inactivate Gram-negative bacteria upon visible light irradiation but left Gram-positive bacteria less damaged, which can serve as a blueprint for the development of novel narrow-spectrum agents to replenish the current arsenal of photodynamic antimicrobial chemotherapy (PACT).

Graphical abstract: A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria

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Article information

DOI
https://doi.org/10.1039/C5CC00174A
Article type
Communication
Submitted
08 Jan 2015
Accepted
01 Apr 2015
First published
01 Apr 2015

Chem. Commun., 2015,51, 7923-7926

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A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria

K. Li, Y. Zhang, G. Jiang, Y. Hou, B. Zhang, Q. Zhou and X. Wang, Chem. Commun., 2015, 51, 7923 DOI: 10.1039/C5CC00174A

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