Issue 37, 2015
From the journal:

Chemical Communications

A plasmonic aptasensor for ultrasensitive detection of thrombin via arrested rolling circle amplification†

Sai Wang,a   Sai Bi,*a   Zonghua Wang,*a   Jianfei Xia,a   Feifei Zhang,a   Min Yang,a   Rijun Gui,a   Yanhui Lia  and  Yanzhi Xiaa  

* Corresponding authors

a College of Chemical Science and Engineering, Laboratory of Fiber Materials and Modern Textiles, The Growing Base for State Key Laboratory, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles, Qingdao University, Qingdao 266071, P. R. China
E-mail: bisai11@126.com, wangzonghua@qdu.edu.cn

Abstract

A sensitive signal generation mechanism for gold nanoparticle growth by reducing gold ions with hydrogen peroxide is applied in a plasmonic aptasensor, achieving naked-eye detection of thrombin at the single-molecule level based on the specific interaction of aptamer–thrombin via an arrested rolling circle amplification to yield horseradish peroxidase (HRP)-mimicking DNAzymes as biocatalysts.

Graphical abstract: A plasmonic aptasensor for ultrasensitive detection of thrombin via arrested rolling circle amplification

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Article information

DOI
https://doi.org/10.1039/C5CC02069G
Article type
Communication
Submitted
12 Mar 2015
Accepted
23 Mar 2015
First published
23 Mar 2015

Chem. Commun., 2015,51, 7927-7930

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A plasmonic aptasensor for ultrasensitive detection of thrombin via arrested rolling circle amplification

S. Wang, S. Bi, Z. Wang, J. Xia, F. Zhang, M. Yang, R. Gui, Y. Li and Y. Xia, Chem. Commun., 2015, 51, 7927 DOI: 10.1039/C5CC02069G

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