Issue 37, 2015
From the journal:

Chemical Communications

A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals†

Fang Si, ORCID logo ab   Yang Liu,c   Kelu Yana  and  Wenwan Zhong*bc  

* Corresponding authors

a College of Chemistry, Chemical and Biological Engineering, Donghua University, Shanghai 201620, P. R. China

b Department of Chemistry, University of California, Riverside 92521, USA
E-mail: wenwan.zhong@ucr.edu
Fax: +1-951-827-4732
Tel: +1-951-827-4925

c Environmental Toxicology Program, University of California, Riverside 92521, USA

Abstract

An amine-reactive fluorogenic molecule specifically turned on by superoxide radicals (O2˙−) was synthesized and coupled to a mitochondrial (MT) targeting peptide. The obtained probe showed superior uptake and MT targeting capabilities; and successfully detected the change in O2˙− levels in cells treated with chemical stimuli or single-walled carbon nanotubes.

Graphical abstract: A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals

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Article information

DOI
https://doi.org/10.1039/C5CC01075F
Article type
Communication
Submitted
05 Feb 2015
Accepted
24 Mar 2015
First published
25 Mar 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 7931-7934

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A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals

F. Si, Y. Liu, K. Yan and W. Zhong, Chem. Commun., 2015, 51, 7931 DOI: 10.1039/C5CC01075F

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