A chemoenzymatic approach for synthesizing heparan sulfate oligosaccharides with a reactive diazoacetyl saccharide residue is reported. The resultant oligosaccharides were demonstrated to serve as specific inhibitors for heparan sulfate sulfotransferases, offering a new set of tools to probe the structural selectivity for heparan sulfate-binding proteins.
W. Zhou, P. Hsieh, Y. Xu, T. R. O’Leary, X. Huang and J. Liu, Chem. Commun., 2015, 51, 11019 DOI: 10.1039/C5CC02008E
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