A fluorescent probe for H2S in vivo with fast response and high sensitivity

H. D. Li; Q. C. Yao; J. L. Fan; N. Jiang; J. Y. Wang; J. Xia; X. J. Peng

doi:10.1039/C5CC06612C

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A fluorescent probe for H₂S in vivo with fast response and high sensitivity†

H. D. Li,^a Q. C. Yao,^a J. L. Fan,^a N. Jiang,^a J. Y. Wang,^b J. Xia^b and X. J. Peng*^a

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China
E-mail: pengxj@dlut.edu.cn

^b Department School of life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China

Abstract

In this work, we design and synthesize a new near-infrared (NIR) ratiometric fluorescent probe FD-H₂S for the highly sensitive (DL 68.2 nM) detection of H₂S with fast response (15 s), large emission shift (220 nm) and excellent enhancement (168-fold in ratiometric value). The probe could be applied for monitoring and imaging of exogenous or endogenous H₂S in live MCF-7 cells and in live mice with the fastest response.

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Article information

DOI: https://doi.org/10.1039/C5CC06612C
Article type: Communication
Submitted: 07 Aug 2015
Accepted: 15 Sep 2015
First published: 15 Sep 2015

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Chem. Commun., 2015,51, 16225-16228

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A fluorescent probe for H₂S in vivo with fast response and high sensitivity

H. D. Li, Q. C. Yao, J. L. Fan, N. Jiang, J. Y. Wang, J. Xia and X. J. Peng, Chem. Commun., 2015, 51, 16225 DOI: 10.1039/C5CC06612C

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Chemical Communications