An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor™ as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.
![Graphical abstract: Fluorination of 2-substituted benzo[b]furans with Selectfluor™](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4OB02691H&imageInfo.ImageIdentifier.Year=2015)
M. Wang, X. Liu, L. Zhou, J. Zhu and X. Sun, Org. Biomol. Chem., 2015, 13, 3190 DOI: 10.1039/C4OB02691H
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