Issue 46, 2015
From the journal:

Organic & Biomolecular Chemistry

Regioselective synthesis of 2H-indazoles through Ga/Al- and Al-mediated direct alkylation reactions of indazoles†

Mei-Huey Lin,*a   Han-Jun Liu,a   Wei-Cheng Lin,a   Chung-Kai Kuoa  and  Tsung-Hsun Chuanga  

* Corresponding authors

a Department of Chemistry, National Changhua University of Education, Changhua, Taiwan 50007
E-mail: mhlin@cc.ncue.edu.tw

Abstract

A procedure has been developed for the regioselective, high yielding synthesis of 2H-indazoles that involves direct alkylation of indazoles with various allyl and benzyl bromides, and α-bromocarbonyl compounds.

Graphical abstract: Regioselective synthesis of 2H-indazoles through Ga/Al- and Al-mediated direct alkylation reactions of indazoles

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Article information

DOI
https://doi.org/10.1039/C5OB01747E
Article type
Paper
Submitted
20 Aug 2015
Accepted
29 Sep 2015
First published
29 Sep 2015

Org. Biomol. Chem., 2015,13, 11376-11381

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Regioselective synthesis of 2H-indazoles through Ga/Al- and Al-mediated direct alkylation reactions of indazoles

M. Lin, H. Liu, W. Lin, C. Kuo and T. Chuang, Org. Biomol. Chem., 2015, 13, 11376 DOI: 10.1039/C5OB01747E

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