Issue 9, 2015

Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

Abstract

A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.

Graphical abstract: Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

Supplementary files

Article information

Article type
Research Article
Submitted
06 Jun 2015
Accepted
07 Jul 2015
First published
13 Jul 2015

Org. Chem. Front., 2015,2, 1071-1075

Author version available

Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

H. Zhang, P. V. Bonnesen and K. Hong, Org. Chem. Front., 2015, 2, 1071 DOI: 10.1039/C5QO00181A

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