Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry†
Abstract
Secretomics, the comprehensive study of cell releasates, offers a non-invasive approach to understanding cell heterogeneity. We here propose single cell small molecule secretomics using micro-droplet arrays and mass spectrometry as a new repertoire of omics technologies. The present method revealed the heterogeneity of secreted small molecules from individual single cells without the use of any invasive processes.