Issue 22, 2015

Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry

Abstract

Secretomics, the comprehensive study of cell releasates, offers a non-invasive approach to understanding cell heterogeneity. We here propose single cell small molecule secretomics using micro-droplet arrays and mass spectrometry as a new repertoire of omics technologies. The present method revealed the heterogeneity of secreted small molecules from individual single cells without the use of any invasive processes.

Graphical abstract: Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry

Supplementary files

Article information

Article type
Communication
Submitted
09 Oct 2014
Accepted
29 Jan 2015
First published
30 Jan 2015

RSC Adv., 2015,5, 16968-16971

Author version available

Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry

H. Fujita, T. Esaki, T. Masujima, A. Hotta, S. H. Kim, H. Noji and T. M. Watanabe, RSC Adv., 2015, 5, 16968 DOI: 10.1039/C4RA12021C

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