Issue 11, 2015
From the journal:

RSC Advances

Base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes†

Xuxue Zhang,a   Yingyin Lin,a   Juan Zhanga  and  Song Cao*a  

* Corresponding authors

a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China
E-mail: scao@ecust.edu.cn
Fax: +86-21-64252603
Tel: +86-21-64253452

Abstract

Direct α-fluorovinylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes via nucleophilic vinylic substitution reaction (SNV) under the assistance of KHMDS or NaH at room temperature is described.

Graphical abstract: Base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes

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Article information

DOI
https://doi.org/10.1039/C4RA13761B
Article type
Communication
Submitted
04 Nov 2014
Accepted
22 Dec 2014
First published
22 Dec 2014

RSC Adv., 2015,5, 7905-7908

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Base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes

X. Zhang, Y. Lin, J. Zhang and S. Cao, RSC Adv., 2015, 5, 7905 DOI: 10.1039/C4RA13761B

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