Issue 72, 2015
From the journal:

RSC Advances

Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives†

Nadine Jacobs,a   Steffen Lang,b   Robin Panisch,c   Gunther Wittstock,a   Ulrich Grothb  and  Hamid R. Nasiri*c  

* Corresponding authors

a Carl von Ossietzky University of Oldenburg, Faculty of Mathematics and Natural Sciences, Institute of Chemistry, D-26111 Oldenburg, Germany

b Fachbereich Chemie und Konstanz Research School Chemical Biology, Universität Konstanz, Postfach M-720, D-78457 Konstanz, Germany

c Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Straße 7, D-60438 Frankfurt am Main, Germany
E-mail: Nasiri@nmr.uni-frankfurt.de

Abstract

The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies. To enable a structure–toxicity-relationship of the natural product, eleven novel synthetic derivatives with different electrochemical properties were synthesized and tested. Derivative 5 revealed a GI50 in the low μM range, being more active than the actual natural product. A clear correlation was found between the experimental and the calculated data.

Graphical abstract: Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

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Article information

DOI
https://doi.org/10.1039/C5RA11078E
Article type
Paper
Submitted
10 Jun 2015
Accepted
26 Jun 2015
First published
29 Jun 2015
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2015,5, 58561-58565

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Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

N. Jacobs, S. Lang, R. Panisch, G. Wittstock, U. Groth and H. R. Nasiri, RSC Adv., 2015, 5, 58561 DOI: 10.1039/C5RA11078E

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