Effect of imidazolium room-temperature ionic liquids on aggregation of amphotericin B: a circular dichroism study

Abstract

The nature of the anion of imidazolium-based ionic liquids was found to control the aggregate–monomer equilibrium of amphotericin B. This is in contrast to aqueous solutions of inorganic salts and imidazolium-based ionic liquids, which were previously found to favor the disaggregation of amphotericin B. The results further establish the designer solvent ability of ionic liquids, specifically as it relates to their ability to influence intermolecular interactions.