A novel magnetic drug delivery nanocomplex with a cisplatin-conjugated Fe3O4 core and a PEG-functionalized mesoporous silica shell for enhancing cancer drug delivery efficiency

Chandrababu Rejeeth; Raju Vivek; Soundarapandian Kannan

doi:10.1039/C5RA19274A

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A novel magnetic drug delivery nanocomplex with a cisplatin-conjugated Fe₃O₄ core and a PEG-functionalized mesoporous silica shell for enhancing cancer drug delivery efficiency†

Chandrababu Rejeeth,‡*^a Raju Vivek ‡^a and Soundarapandian Kannan^ab

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* Corresponding authors

^a Proteomics & Molecular Cell Physiology Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-641 046, TN, India
E-mail: crejee@gmail.com, crejee@sjtu.edu.cn
Tel: +91 9486138085

^b Department of Zoology, Periyar University, Salem-636 001, TN, India

Abstract

Towards the rapid synthesis and efficient action of a smart drug delivery nanosystem based on coating a layer of PEG functionalized mesoporous silica onto a cisplatin (CDDP) conjugated Fe₃O₄ nanocomposite. We achieve a number of nanocomplex enhancements of the biomagnetic carriers’ therapeutic functionality. Such a novel drug-delivery nanosystem has potential applications in cancer treatment.

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Article information

DOI: https://doi.org/10.1039/C5RA19274A
Article type: Communication
Submitted: 18 Sep 2015
Accepted: 21 Oct 2015
First published: 22 Oct 2015

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RSC Adv., 2015,5, 94534-94538

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A novel magnetic drug delivery nanocomplex with a cisplatin-conjugated Fe₃O₄ core and a PEG-functionalized mesoporous silica shell for enhancing cancer drug delivery efficiency

C. Rejeeth, R. Vivek and S. Kannan, RSC Adv., 2015, 5, 94534 DOI: 10.1039/C5RA19274A

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