AlbA is a radical SAM enzyme catalyzing the formation of three unusual thioether bonds in the antibiotic subtilosin A. We demonstrate here that AlbA catalyzes direct Cα H-atom abstraction and likely contains three essential [4Fe–4S] centers. This leads us to propose novel mechanistic perspectives for thioether bond catalysis by radical SAM enzymes.
A. Benjdia, A. Guillot, B. Lefranc, H. Vaudry, J. Leprince and O. Berteau, Chem. Commun., 2016, 52, 6249 DOI: 10.1039/C6CC01317A
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