Issue 37, 2016
From the journal:

Chemical Communications

Rh(iii)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes†

Xiaolei Huang,a   Wenbo Liang,a   Yang Shia  and  Jingsong You*a  

* Corresponding authors

a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China
E-mail: jsyou@scu.edu.cn

Abstract

In this work, we report novel Rh(III)-catalyzed chemoselective functionalizations of tertiary aniline N-oxides with alkynes, including annulation via the sequential C(sp2)–H and C(sp3)–N activation for the formation of N-alkylindoles and an O-atom transfer (OAT) process for the synthesis of acetophenones.

Graphical abstract: Rh(iii)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes

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Article information

DOI
https://doi.org/10.1039/C6CC02217K
Article type
Communication
Submitted
13 Mar 2016
Accepted
05 Apr 2016
First published
05 Apr 2016

Chem. Commun., 2016,52, 6253-6256

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Rh(III)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes

X. Huang, W. Liang, Y. Shi and J. You, Chem. Commun., 2016, 52, 6253 DOI: 10.1039/C6CC02217K

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