Issue 43, 2016
From the journal:

Chemical Communications

bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules†

Anil P. Jagtap,a   Michel-Andreas Geiger,b   Daniel Stöppler,b   Marcella Orwick-Rydmark,‡b   Hartmut Oschkinat*b  and  Snorri Th. Sigurdsson*a  

* Corresponding authors

a University of Iceland, Department of Chemistry, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland
E-mail: snorrisi@hi.is

b NMR supported structural biology, Leibniz-Institut for Molecular Biology (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany
E-mail: oschkinat@fmp-berlin.de

Abstract

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.

Graphical abstract: bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

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Article information

DOI
https://doi.org/10.1039/C6CC01813K
Article type
Communication
Submitted
29 Feb 2016
Accepted
03 May 2016
First published
10 May 2016

Chem. Commun., 2016,52, 7020-7023

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bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

A. P. Jagtap, M. Geiger, D. Stöppler, M. Orwick-Rydmark, H. Oschkinat and S. Th. Sigurdsson, Chem. Commun., 2016, 52, 7020 DOI: 10.1039/C6CC01813K

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