Issue 93, 2016
From the journal:

Chemical Communications

An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules†

Jie Li,‡a   Linlin Zhang,‡b   Yang Liu,ac   Jing Wen,d   Di Wu,a   Duo Xu,a   Tatiana Segura,a   Jing Jin,*e   Yunfeng Lu*a  and  Hui Wang*b  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
E-mail: luucla@ucla.edu

b Department of Nuclear Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Jiao Tong University, Shanghai 200092, China
E-mail: wanghuishanghai@hotmail.com

c Key Laboratory of Functional Polymer Materials of Ministry of Education and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

d Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA

e Diagnosis Biotech Co., Ltd, No. 3 Hengda Road, Qixia District, Nanjing, Jiangsu 210038, China
E-mail: jjin.seu@gmail.com

Abstract

An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.

Graphical abstract: An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

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Article information

DOI
https://doi.org/10.1039/C6CC05099A
Article type
Communication
Submitted
18 Jun 2016
Accepted
16 Sep 2016
First published
28 Sep 2016

Chem. Commun., 2016,52, 13608-13611

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An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

J. Li, L. Zhang, Y. Liu, J. Wen, D. Wu, D. Xu, T. Segura, J. Jin, Y. Lu and H. Wang, Chem. Commun., 2016, 52, 13608 DOI: 10.1039/C6CC05099A

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