Issue 6, 2016

Recent developments in the synthesis and utilization of chiral β-aminophosphine derivatives as catalysts or ligands

Abstract

In the last few years, the research area of chiral β-aminophosphines capable of promoting a wide range of diverse organic transformations has attracted more attention. Their derivatives constitute attractive reagents towards this end, due to their stability, low toxicity and ease of handling. These novel β-aminophosphine derivatives are potentially useful as organocatalysts and ligands in metal-catalysed reactions. In particular, chiral β-aminophosphines have recently emerged as powerful phosphine catalysts in asymmetric synthesis and catalysis. The asymmetric transformations to which metal complexes of these ligands have been applied include palladium-catalysed allylic substitutions and copper-catalysed 1,4-additions to enones among others. This review summarizes the most significant developments in the area of synthesis and application of chiral β-aminophosphine derivatives, providing a detailed overview of the current state of the art and including future aspects.

Graphical abstract: Recent developments in the synthesis and utilization of chiral β-aminophosphine derivatives as catalysts or ligands

Article information

Article type
Review Article
Submitted
13 Jun 2015
First published
18 Jan 2016

Chem. Soc. Rev., 2016,45, 1657-1677

Author version available

Recent developments in the synthesis and utilization of chiral β-aminophosphine derivatives as catalysts or ligands

W. Li and J. Zhang, Chem. Soc. Rev., 2016, 45, 1657 DOI: 10.1039/C5CS00469A

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