Issue 11, 2016

Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release

Abstract

At present, diselenide bonds have been considered as a novel dual redox-sensitive linkage. Nevertheless, few studies have focused on diselenide-linked polysaccharide as new biological materials. In this work, the diselenide-linked mPEGylated starch amphiphilic copolymers (mPEG-SeSe-St), which combined the biocompatibility of polysaccharide and the stimuli-responsiveness of diselenide linkages, were developed as a novel type of PEG-detachable drug vector for rapid drug release. The amphiphilic design of the mPEG-SeSe-St enabled the formation of self-assembled micelles with spherical core–shell structures in aqueous solution. The data of well-ordered appraisals demonstrated that mPEG-SeSe-St could be disrupted in the presence of a low concentration of hydrogen peroxide (H2O2, 0.1% (v/v)) or glutathione (GSH, 1 mM). The process of diselenide bonds' more rapid degradation than disulfide bonds led to a synergistically enhanced release of loaded anticancer drugs (DOX) in cellular environments. These results, combined with cell viability measurements and confocal laser scanning microscopy (CLSM), indicated that mPEG-SeSe-St micelles might have appeared as a refined platform for cancer therapy.

Graphical abstract: Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release

Supplementary files

Article information

Article type
Paper
Submitted
09 Nov 2015
Accepted
12 Jan 2016
First published
15 Jan 2016

RSC Adv., 2016,6, 9164-9174

Author version available

Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release

M. Chen, C. Gao, S. Lü, Y. Chen and M. Liu, RSC Adv., 2016, 6, 9164 DOI: 10.1039/C5RA23618E

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