A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy†
Abstract
A novel tetra-doxorubicin-tailed polyethylene glycol via benzoic-imine bond linkage was synthesized and self-assembled to a pH-sensitive prodrug micelle. This micelle not only effectively entered cancer cells but also quickly released doxorubicin (DOX) in tumor sites to exert anticancer activity in vitro.