A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach

Pengfeng Guo; Changcheng Wang; Ya Chen; Caijun Ou; Hangqi Jiang; Weifeng Chen; Weixin Chen; Hua Cao

doi:10.1039/C6RA05815A

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A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach†

Pengfeng Guo,‡^a Changcheng Wang,‡^a Ya Chen,^a Caijun Ou,^a Hangqi Jiang,^a Weifeng Chen,^a Weixin Chen^a and Hua Cao*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, P. R. China
E-mail: caohua@gdpu.edu.cn
Fax: +86 76088207939

Abstract

A novel one pot, metal-free, three-component domino reaction for the formation of furan derivatives has been developed from 3-phenylpropiolaldehyde, 1,3-dicarbonyl compounds and aromatic amine or aliphatic acid. This transformation provided a general and facile access to the construction of C–O and C–N bonds to prepare various bioactive furans in good yields.

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Article information

DOI: https://doi.org/10.1039/C6RA05815A
Article type: Communication
Submitted: 04 Mar 2016
Accepted: 12 Apr 2016
First published: 14 Apr 2016

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RSC Adv., 2016,6, 39563-39567

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A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach

P. Guo, C. Wang, Y. Chen, C. Ou, H. Jiang, W. Chen, W. Chen and H. Cao, RSC Adv., 2016, 6, 39563 DOI: 10.1039/C6RA05815A

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A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach†

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A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach

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