Issue 103, 2016

Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

Abstract

Mg/N double-doped carbon dots (CDs) with a quantum yield up to 84.6% were synthesized by a one-step hydrothermal method, and the as-prepared CDs were then successfully used as carriers for an insoluble photosensitizer (chlorin e6, Ce6). Besides the high fluorescence quantum yield of the CDs, the short donor–acceptor distance and excessive acceptors per donor of the designed CDs–Ce6 system contributed to the high fluorescence resonance energy transfer (FRET) efficiency (up to 84%) and final enhanced photodynamic reaction. The CDs–Ce6 system showed excellent hydrophilicity and particularly tunable FRET efficiency. Its singlet oxygen (SO) quantum yield was double that of pure Ce6, and a significant photodynamic therapy (PDT) effect was proven on HepG2 cancer cells.

Graphical abstract: Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2016
Accepted
09 Oct 2016
First published
12 Oct 2016

RSC Adv., 2016,6, 101447-101451

Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

K. Yang, F. Li, W. Che, X. Hu, C. Liu and F. Tian, RSC Adv., 2016, 6, 101447 DOI: 10.1039/C6RA20412K

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