Issue 2, 2017

Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

Abstract

We demonstrate a novel system for inducing clustering of cell surface receptors via recognition peptide segments displayed on exosomes, leading to receptor activation. With this system, targeting of receptor-expressing cells and facilitation of the endocytic uptake of exosomes, which contained the anti-cancer protein saporin, were successfully achieved, leading to cell death.

Graphical abstract: Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

Supplementary files

Article information

Article type
Communication
Submitted
16 Aug 2016
Accepted
08 Nov 2016
First published
08 Nov 2016

Chem. Commun., 2017,53, 317-320

Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

I. Nakase, N. Ueno, M. Katayama, K. Noguchi, T. Takatani-Nakase, N. B. Kobayashi, T. Yoshida, I. Fujii and S. Futaki, Chem. Commun., 2017, 53, 317 DOI: 10.1039/C6CC06719K

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