Issue 2, 2017
From the journal:

Chemical Communications

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation†

Nathalie Busschaert,ab   Sam Thompson*bc  and  Andrew D. Hamilton*ab  

* Corresponding authors

a Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA
E-mail: andrew.hamilton@nyu.edu

b Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: sam.thompson@chem.ox.ac.uk

c Chemistry, University of Southampton, Southampton, UK
E-mail: sam.thompson@soton.ac.uk

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

Graphical abstract: An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

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Article information

DOI
https://doi.org/10.1039/C6CC07787K
Article type
Communication
Submitted
25 Sep 2016
Accepted
07 Nov 2016
First published
07 Nov 2016

Chem. Commun., 2017,53, 313-316

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An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

N. Busschaert, S. Thompson and A. D. Hamilton, Chem. Commun., 2017, 53, 313 DOI: 10.1039/C6CC07787K

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