Issue 8, 2017
From the journal:

Chemical Communications

Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications†

Qingyang Zhang,‡ab   Qinghua Wang,‡ab   Shengnan Xu,a   Limin Zuo,c   Xuefu Youc  and  Hai-Yu Hu*ab  

* Corresponding authors

a State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
E-mail: haiyu.hu@imm.ac.cn

b Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

c Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Abstract

Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.

Graphical abstract: Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

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Article information

DOI
https://doi.org/10.1039/C6CC08292K
Article type
Communication
Submitted
14 Oct 2016
Accepted
01 Dec 2016
First published
01 Dec 2016

Chem. Commun., 2017,53, 1366-1369

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Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

Q. Zhang, Q. Wang, S. Xu, L. Zuo, X. You and H. Hu, Chem. Commun., 2017, 53, 1366 DOI: 10.1039/C6CC08292K

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