Issue 10, 2017

In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds

Abstract

A new three-component reaction, namely condensation–anti-Michael addition–aromatization, enabling the construction of benzylic compounds is disclosed. This reaction can not only act as an alternative approach to regioselective Csp2–H trifluoromethylation of arenes through an “aromatic to be” strategy, but also provides a simple, convenient, step-economic, and practical strategy for the in situ generation of electrophilic p-(trifluoromethyl)benzyl species under extremely mild conditions.

Graphical abstract: In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
22 Nov 2016
Accepted
04 Jan 2017
First published
04 Jan 2017

Chem. Commun., 2017,53, 1668-1671

In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds

J. Dong, S. Xin, Y. Wang, L. Pan and Q. Liu, Chem. Commun., 2017, 53, 1668 DOI: 10.1039/C6CC09268C

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