Issue 10, 2017

Palladium(ii)-catalyzed direct O-alkenylation of 2-arylquinazolinones with N-tosylhydrazones: an efficient route to O-alkenylquinazolines

Abstract

An efficient Pd(II)-catalyzed direct O-alkenylation of 2-arylquinazolinones with simple ketone-derived N-tosylhydrazones is reported. In this reaction, O-alkenylquinazolines were obtained in good yields, with excellent functional group tolerance. Pd–carbene migratory insertion is proposed as the key step in the reaction mechanism.

Graphical abstract: Palladium(ii)-catalyzed direct O-alkenylation of 2-arylquinazolinones with N-tosylhydrazones: an efficient route to O-alkenylquinazolines

Supplementary files

Article information

Article type
Communication
Submitted
26 Nov 2016
Accepted
22 Dec 2016
First published
03 Jan 2017

Chem. Commun., 2017,53, 1672-1675

Palladium(II)-catalyzed direct O-alkenylation of 2-arylquinazolinones with N-tosylhydrazones: an efficient route to O-alkenylquinazolines

R. Lingayya, M. Vellakkaran, K. Nagaiah, P. R. Tadikamalla and J. B. Nanubolu, Chem. Commun., 2017, 53, 1672 DOI: 10.1039/C6CC09445G

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