Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Zhaokui Jin; Yanyuan Wen; Liwei Xiong; Tian Yang; Penghe Zhao; Liwei Tan; Tianfu Wang; Zhiyong Qian; Bao-Lian Su; Qianjun He

doi:10.1039/C7CC01576C

Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy†

Zhaokui Jin,‡^a Yanyuan Wen,‡^a Liwei Xiong,‡^b Tian Yang,^a Penghe Zhao,^a Liwei Tan,^c Tianfu Wang,^a Zhiyong Qian,

^c Bao-Lian Su^d and Qianjun He

*^a

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* Corresponding authors

^a National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China
E-mail: nanoflower@126.com

^b Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, Wuhan, China

^c State Key Laboratory of Biotherapy and Cancer Centre, Collaborative Innovation Centre for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

^d State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

Abstract

A new H₂O₂-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H₂O₂-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

Chemical Communications

Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy†

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Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

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