The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.
B. Ridder, D. S. Mattes, A. Nesterov-Mueller, F. Breitling and M. A. R. Meier, Chem. Commun., 2017, 53, 5553 DOI: 10.1039/C7CC01945A
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