Issue 52, 2017

Novel chemical probes for the investigation of nonribosomal peptide assembly

Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

Graphical abstract: Novel chemical probes for the investigation of nonribosomal peptide assembly

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2017
Accepted
12 Jun 2017
First published
19 Jun 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 7088-7091

Novel chemical probes for the investigation of nonribosomal peptide assembly

Y. T. C. Ho, D. J. Leng, F. Ghiringhelli, I. Wilkening, D. P. Bushell, O. Köstner, E. Riva, J. Havemann, D. Passarella and M. Tosin, Chem. Commun., 2017, 53, 7088 DOI: 10.1039/C7CC02427D

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