A luminescent lanthanide approach towards direct visualization of primary cilia in living cells

Hongguang Li; Rongfeng Lan; Chi-Fai Chan; Guochen Bao; Chen Xie; Pak-Ho Chu; William C. S. Tai; Shuai Zha; Jing-Xiang Zhang; Ka-Leung Wong

doi:10.1039/C7CC03021E

A luminescent lanthanide approach towards direct visualization of primary cilia in living cells†

Hongguang Li,

‡^a Rongfeng Lan,

‡^a Chi-Fai Chan,^a Guochen Bao,^a Chen Xie,^a Pak-Ho Chu,^a William C. S. Tai,

^b Shuai Zha,^a Jing-Xiang Zhang^ac and Ka-Leung Wong

*^ad

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* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR
E-mail: klwong@hkbu.edu.hk
Tel: +852-3411-2370

^b Department of Applied Biological and Chemical Technology, Hong Kong Polytechnic University, Hung Hum, Hong Kong SAR

^c School of Chemistry and Environment Engineering, Hanshan Normal University, Chaozhou, Guangdong, China

^d Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR

Abstract

We report a direct imaging tool, HGEu001, for primary cilia in living cells, which is specific, and based on the UV light or near infrared laser (via two-photon excitation) induced long-lived europium luminescence.

Chemical Communications

A luminescent lanthanide approach towards direct visualization of primary cilia in living cells†

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A luminescent lanthanide approach towards direct visualization of primary cilia in living cells

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