Issue 37, 2017

Novel nanoparticles with Cr3+ substituted ferrite for self-regulating temperature hyperthermia

Abstract

For hyperthermia to be used under clinical conditions for cancer therapeutics the temperature regulation needs to be precise and accurately controllable. In the case of the metal nanoparticles used for such activities, a high coercivity is a prerequisite in order to couple more energy in a single heating cycle for efficient and faster differential heating. The chemically stable Co–Zn ferrite nanoparticles have typically not been used in such self-regulating hyperthermia temperature applications to date due to their low Curie temperature usually accompanied by a poor coercivity. The latter physical property limitation under clinically applied magnetic field conditions (frequency: 100 kHz, intensity: 200 Oe) restricts the transfer of a reasonable heat energy, and thus limits the hyperthermia efficiency. Here, we report a novel Cr3+ substituted Co–Zn ferrite (Zn0.54Co0.46Cr0.6Fe1.4O4), whose Curie temperature and coercivity values are 45.7 °C and 174 Oe, respectively. Under clinically acceptable magnetic field conditions, the temperature of these nanoparticle suspensions can be self-regulated to 44.0 °C and, most importantly with a specific absorption rate (SAR) of 774 W kg−1, which is two-fold higher than the SAR standard for magnetic nanoparticles used in hyperthermia (300 W kg−1). The evaluation of the in vitro cytotoxicity of the nanoparticles reports a low toxicity, which points to a novel set of magnetic nanoparticles for use in self-regulating hyperthermia.

Graphical abstract: Novel nanoparticles with Cr3+ substituted ferrite for self-regulating temperature hyperthermia

Supplementary files

Article information

Article type
Paper
Submitted
03 Apr 2017
Accepted
24 Jun 2017
First published
26 Jun 2017

Nanoscale, 2017,9, 13929-13937

Novel nanoparticles with Cr3+ substituted ferrite for self-regulating temperature hyperthermia

W. Zhang, X. Zuo, Y. Niu, C. Wu, S. Wang, S. Guan and S. R. P. Silva, Nanoscale, 2017, 9, 13929 DOI: 10.1039/C7NR02356A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements