Issue 4, 2017
From the journal:

Organic & Biomolecular Chemistry

Enantioselective synthesis of spirooxindole benzoquinolizines via organo-catalyzed cascade reactions†

Yu Tan,a   Er-Lu Feng,a   Qiang-Sheng Sun,a   Hua Lin,*b   Xun Sun,b   Guo-Qiang Lina  and  Xing-Wen Sun*ac  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: sunxingwen@fudan.edu.cn

b School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P. R. China.
E-mail: linh@fudan.edu.cn

c Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, China

Abstract

A Michael–Mannich–hemiaminalization–dehydration cascade reaction was developed for the construction of spirooxindole benzoquinolizine derivatives. Additionally, spirooxindole benzoindolizidine was prepared conveniently through a ring-contracted rearrangement reaction from spirooxindole benzoquinolizine.

Graphical abstract: Enantioselective synthesis of spirooxindole benzoquinolizines via organo-catalyzed cascade reactions

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Article information

DOI
https://doi.org/10.1039/C6OB02157C
Article type
Communication
Submitted
04 Oct 2016
Accepted
27 Oct 2016
First published
27 Oct 2016

Org. Biomol. Chem., 2017,15, 778-781

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Enantioselective synthesis of spirooxindole benzoquinolizines via organo-catalyzed cascade reactions

Y. Tan, E. Feng, Q. Sun, H. Lin, X. Sun, G. Lin and X. Sun, Org. Biomol. Chem., 2017, 15, 778 DOI: 10.1039/C6OB02157C

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