19F CEST imaging probes for metal ion detection

Abstract

For detecting metal ions with ¹⁹F chemical exchange saturation transfer magnetic resonance imaging (¹⁹F CEST MRI), a class of novel fluorinated chelators with diverse fluorine contents and chelation properties were conveniently synthesized on gram scales. Among them, a DTPA-derived chelator with high sensitivity and selectivity was identified as a novel ¹⁹F CEST imaging probe for simultaneously detecting multiple metal ions.