Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407†
F. I.
Zubkov, 
*a
E. A.
Kvyatkovskaya,
a
E. V.
Nikitina,
a
P. N.-A.
Amoyaw,
a
V. V.
Kouznetsov,
b
V. N.
Khrustalev
d
*a
E. A.
Kvyatkovskaya,
a
E. V.
Nikitina,
a
P. N.-A.
Amoyaw,
a
V. V.
Kouznetsov,
b
V. N.
Khrustalev
d
Abstract
It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products – 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.
![Graphical abstract: Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7OB01207A&imageInfo.ImageIdentifier.Year=2017)
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