Issue 23, 2017

Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

Abstract

Tetrafluoroethylene-containing azides are accessed in two steps (one pot) from tetrafluoroalkyl bromides by metalation and reaction with electrophilic azides. Subsequent copper(I)-catalyzed azide–alkyne cycloaddition afforded N-tetrafluoroethyl and N-tetrafluoroethylene 4-substituted 1,2,3-triazoles. In addition, the protocol for the synthesis of 4,5-disubstituted 1,2,3-triazoles is presented.

Graphical abstract: Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

Supplementary files

Article information

Article type
Communication
Submitted
11 May 2017
Accepted
18 May 2017
First published
18 May 2017
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2017,15, 4962-4965

Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

S. Voltrová, M. Muselli, J. Filgas, V. Matoušek, B. Klepetářová and P. Beier, Org. Biomol. Chem., 2017, 15, 4962 DOI: 10.1039/C7OB01151B

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