Issue 23, 2017
From the journal:

Organic & Biomolecular Chemistry

Sulfinyl isobutyramide as an auxiliary for palladium(ii)-catalyzed C–H arylation and iodination of benzylamine derivatives†

Rui Wang, ORCID logo ‡ab   Yongzheng Ding ORCID logo ‡ab  and  Gang Li ORCID logo *a  

* Corresponding authors

a Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, P. R. China
E-mail: gangli@fjirsm.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

A novel readily available bidentate 2-methylsulfinyl isobutyramide directing group has been developed for benzylamine derivatives. It promoted ortho-C–H arylation and iodination of various substrates in good to excellent yields. The auxiliary is promising to be used in organic synthesis due to its versatility and convenient preparation from inexpensive materials.

Graphical abstract: Sulfinyl isobutyramide as an auxiliary for palladium(ii)-catalyzed C–H arylation and iodination of benzylamine derivatives

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Article information

DOI
https://doi.org/10.1039/C7OB01163F
Article type
Communication
Submitted
12 May 2017
Accepted
24 May 2017
First published
25 May 2017

Org. Biomol. Chem., 2017,15, 4966-4970

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Sulfinyl isobutyramide as an auxiliary for palladium(II)-catalyzed C–H arylation and iodination of benzylamine derivatives

R. Wang, Y. Ding and G. Li, Org. Biomol. Chem., 2017, 15, 4966 DOI: 10.1039/C7OB01163F

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