Issue 34, 2017

Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

Abstract

A highly enantioselective intramolecular Rauhut–Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. A series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- and enantioselectivities (up to >20 : 1 dr and >99% ee). And this reaction could be performed on a gram scale using 2 mol% catalyst loading.

Graphical abstract: Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
24 Jul 2017
Accepted
09 Aug 2017
First published
09 Aug 2017

Org. Biomol. Chem., 2017,15, 7097-7101

Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

H. Jin, Q. Zhang, E. Li, P. Jia, N. Li and Y. Huang, Org. Biomol. Chem., 2017, 15, 7097 DOI: 10.1039/C7OB01820G

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