Issue 1, 2017

Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

Abstract

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.

Graphical abstract: Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

Supplementary files

Article information

Article type
Perspective
Submitted
13 May 2016
Accepted
04 Aug 2016
First published
09 Aug 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2017,8, 40-62

Author version available

Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

J. Almond-Thynne, D. C. Blakemore, D. C. Pryde and A. C. Spivey, Chem. Sci., 2017, 8, 40 DOI: 10.1039/C6SC02118B

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