Issue 12, 2018

pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

Abstract

At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant concentration range, i.e. from micromolar to nanomolar at molar ratios of up to 30 : 1.

Graphical abstract: pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2017
Accepted
08 Dec 2017
First published
23 Jan 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 1485-1488

pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

L. A. Serrano, Y. Yang, E. Salvati, F. Stellacci, S. Krol and S. Guldin, Chem. Commun., 2018, 54, 1485 DOI: 10.1039/C7CC07668A

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