Issue 12, 2018

A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy

Abstract

Limited tumor tissue penetration is one of the key impeding factors retarding successful in vivo exploitations of anti-angiogenic cancer therapy. Herein we report on the design of a cell penetrating peptide-decorated lipid nano-assembly which, upon systemic administration, induces significant mouse tumor growth inhibition via enhanced tumor infiltration of encapsulated anti-angiogenic siRNA.

Graphical abstract: A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
05 Nov 2017
Accepted
15 Jan 2018
First published
23 Jan 2018

Chem. Commun., 2018,54, 1489-1492

A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy

P. Majumder, S. Bhunia and A. Chaudhuri, Chem. Commun., 2018, 54, 1489 DOI: 10.1039/C7CC08517F

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